Chemical Properties:
Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureShanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Chlorotrimethylsilane (TMCS) (CAS: 75-77-4) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. Please contact: alvin@ruifuchem.com| Item | Specifications |
| Appearance | Coloress Liquid |
| Purity / Analysis Method | >99.0% (GC) |
| Melting Point | -40℃(lit.) |
| Density (20℃) | 0.858~0.862 |
| Refractive Index n20/D | 1.385~1.390 |
| Methyltrichlorosilane | <0.50% |
| Total Impurities | <1.00% |
| Infrared Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
Description:
Specifications:
Package & Storage:
| Chemical Name | Chlorotrimethylsilane |
| Synonyms | Trimethylchlorosilane; Trimethylsilyl Chloride; TMCS; TMS-Cl |
| CAS Number | 75-77-4 |
| CAT Number | RF-PI2122 |
| Stock Status | In Stock, Production Capacity 350MT/Year |
| Molecular Formula | C3H9ClSi |
| Molecular Weight | 108.64 |
| Boiling Point | 57℃(lit.) |
| Sensitivity | Moisture Sensitive |
| Hydrolytic Sensitivity | 8: Reacts Rapidly with Moisture, Water, Protic Solvents |
| Solubility (Soluble in) | Benzene, Ether, Perchloroethylene |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Chlorotrimethylsilane (TMCS) (CAS: 75-77-4) is a valuable reagent for the protection of the hydroxyl function in organic synthesis. Chlorotrimethylsilane is a colorless fuming liquid with a pungent odor. Readily hydrolyzed with liberation of hydrogen chloride; soluble in benzene, ether and perchloroethylene. Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It is widely used in the syntheses of drugs. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. Chlorotrimethylsilane is the most extensively used derivatization reagent for gas chromatography. The reactions are generally performed under anhydrous conditions although reactions can be performed on samples obtained from water-containing samples. There are considerable opportunities for artifacts stemming from a variety of reasons including off-target reactions with aldehydes and ketones. The rate of reaction of TMCS with nucleophilic targets is comparatively slow compared to other alkylsilyl chlorides and requires the presence of a base catalyst such as pyridine.
